As the world continues to descend into chaos and violence, the Loud family requires the help of an unlikely ally as their brother has fallen at the hands of Chester, who continues to rule over Royal Woods. Meanwhile, Ronnie Anne's forces collide with the mafia in Great Lakes City, Lynn is back on the scene in an unexpected way, and a greater threat still looms over our heroes.

Things are about to get REAL! Lincoln is promoted to leader of the Mortician's Guard, while Ronnie Anne's forces march to Detroit to find more allies. Lynn and Maxie hide out in the upper part of the state as Lisa continues to find out who or what is behind the adults of the world disappearing. Carl climbs up the ladder of power while Chandler faces an internal community conflict.

The Loud children and the other kids continue to fight for survival in a new hostile world that the adults left behind. Lincoln and Lucy run into some old friends, while Ronnie Anne seeks to find allies of her own. Luan and the other sisters roam the land simply to find a place to settle, while Lynn runs into trouble as usual. But there's danger for everyone at every turn.

During a seemingly normal day for the Loud family, their lives are changed forever when Rita, Lynn Sr, Lori and Leni all instantly disappear without a trace. In a world where everyone over the age of 15 has vanished, how will the remaining Loud siblings and other kids perform in the fight for survival, resources and power in the hostile domain all the adults left behind?