Gwen Stacy is an aloof girl living with her roommate MJ, content to beat up thugs, attempting to follow in her father's footsteps. But after she becomes a target of gangsters led by the Don, many superpowered criminals on the loose, the return of a childhood friend, and a rich widow's decade-long plot, Gwen finds herself entangled in a conspiracy bound by her late father's legacy.

To the south lies a town, where the Shogun's hand falters, and the air is sweet with sunflowers. Rumors whisper of a man who sheds blood in the name of God. To the north, a daimyo orders a samurai and his followers to quash any trace of Christian rebellion. Between an iron curse and a spider's blessing, ideals must be tempered. Westward, a wind of change already begins to stir.

Hi! It's me! Is this thing on? Oh jeez... there! Just wanted you to know how we're all doing ever since you left. It's a bit silly, but... hey, why not drop by and see for yourself?

Finding work under the stigma of disability and powers was hard enough for Matt, but returning to NYC only to find his city falling into chaos is more than he can handle. It's up to Matt, friend Jean DeWolff, and rival Chief Carter to put down Carnage. But with Captain Stacy dead, can the 3 vigilantes end her trail of bloodlust at last? A side story to the Amazing Spider-Gwen.