Five Things that Drive Natsume Crazy
Noise. It isn't very obvious, considering his girlfriend and her rather boisterous tendencies, but Natsume Hyuuga actually hates it when his quiet time is interrupted. It's ever a wonder to him that he manages to latch on to his very limited patience whenever his girlfriend saunters into his room or that secluded part in the forest while he reads or rests or just lies down, because the thing about Mikan was that once she starts, she never stops. (He's very thankful for Hotaru's mini inventions, like the invisible earpiece that blocks all noise and tells him what to respond whenever it detects questions. Sometimes it pays to have another genius as a friend.)
Even Class B's ruckus gets too much for him, which was a primary reason for his class-skipping. He believes anyone would want to rip their heads out if they heard Yuu and Sumire and Koko and Mochu and Kitsuneme and Mikan and Ruka - yes, even Ruka, because he keeps screaming at the ever so nonchalant Hotaru - all screaming in some kind of messed-up harmony.
Ruka's pets. Five years after leaving the Academy, Natsume and Ruka both found themselves sharing an apartment, partly out of habit and partly because they believe their respective girlfriends would be demons and that it would be too early to move in (they've got the rest of their lives to deal with the monsters a female body can harbour, so why not take their time right?). Most of their friends (Koko and Mochu especially) laughed about it, saying it was so "gay" and "bromantic" of them, but Natsume didn't really mind - until Ruka started bringing home pets.
Pets. In plural.
At first it was a harmless bunny, reminiscent of Usagi, which he didn't mind. And then there was a kitten. And then a dog, and then a gecko, and then a salamander and a parrot and a wolf. All of which Natsume patiently endured in silence. But when the giraffe came - and no, he didn't give a damn about the fact that the giraffe just got homeless and was a baby and was barely seven feet tall as of the moment - Natsume absolutely put his foot down and contacted the nearest zoo (after ensuring that they had the best animal caretaking services, of course). Ruka sulked about that for weeks, and after the gang's insistence at him making a move to "fix their domestic row", he said yes to Ruka's plea of keeping the Komodo dragon he found wandering the forest during his earlier trip to Indonesia.
Hotaru, the sadistic female, commented on his apparent "whipped-ness", which then prompted him to start living with Mikan, and gave his full points against Hotaru.
Trips to the mall with Mikan and/or Ruka. He thought he'd been prepared well enough, knowing how horrible women could get while shopping, but with Mikan and Ruka, things get a little too out of hand. If it's with Mikan, he always finds himself too involved in dilemmas about apparel and whether it "looks good" on her (which is really problematic because anything looks good on her and in fact, if he were to be completely honest with himself, she looks best without all those clothing). With Ruka, it's pretty much the same, except he actually coaxes Natsume into long-winded opinions that, frankly, always mean "I dunno, maybe".
Ruka. Hotaru, in a separate chapter, can attest fully to this, in addition to all the reasons already written here.
Mikan. Because it's Mikan. No one comes close to Mikan without being driven insane. The effect multiplies hundredfold once you're in love with her. So unfortunately for Natsume, he's receiving the full blow.
Still, it's not like he minds.