When Mario and Luigi made it to the Mushroom Kingdom, they quickly realized that they weren't the only ones who were sneezing. Wherever they looked, people were constantly either sneezing or needing to sneeze. Even if some of them covered their mouths, their sneezes were all impossibly loud and powerful. It didn't matter who did it; males, females, adults, kids... everybody was sneezing nearly every sixty seconds. Toad and Toadette were caught sneezing and blowing themselves backwards. A few sneezy Yoshis tried to hold in their sneezes by covering their noses, but they failed and ended up sneezing some strong, un-Yoshi sneezes. Neither Mario nor Luigi could believe what they were witnessing.

"Mama mia! You're right, Luigi!" Mario said. "What's gotten into everyone?"

"Haaaaah..." Luigi inhaled, then put a hand over his mouth and released another extremely loud sneeze. "CHIYOOOOOOOOOOOOOOOOOOO!" The other characters in this scene, not including Mario, either didn't hear the sneeze or were too busy with their own sneezes to care. Luigi sniffled and rubbed his nose on his forefinger.

"Uh, bless you," Mario said.

"I have no idea what's going on, Mario, but everybody's got it," Luigi said, wiping his hand on his sleeve to clean the spray off of his hand. "Maybe even Princess Peach."

"Peach?!" To say that Mario didn't take this well might as well have been an understatement. "Oh, no. Not Peach! Anybody but-"

"HEEEEEEEEEEEET-" An extremely loud, feminine inhale filled the air and interrupted Mario's sentence, followed by an equally loud and somehow still feminine sneeze, both of which were from none other than Princess Peach herself. "CHHHHHHHHHHHEEEEEEEEEEEEEEEWWWWWWWWWWWWWWWWWWWW!"

Mario, Luigi, and pretty much everybody else could feel the ground shaking beneath them with the power of the sneeze. Mario and Luigi recognized that voice and looked around for who it came from. Then, they saw Peach, who had a bright red tinge on her nose and looked embarrassed from the power of her sneeze. In her hand, she had her pink handkerchief, and she blew her nose quietly into it before wiping her nose. She could see Mario and Luigi running over to her, and both of them couldn't believe what they had just heard.

"Oh, my gosh! Peach!" Mario said. "I've never heard you sneeze like that before!"

"Me neither!" Luigi agreed, and then thought he was being impolite. "Uh, I mean... bless you?"

"I am so sorry, boys," Peach said with a mild sniffle. "I don't know what's causing me and everyone else to sneeze like this, but it's making us all miserable." She then noticed that Mario and Luigi's noses had both turned a bright red as well. "Oh, dear, does it look like you two have the same problem as well?"

Before either of the plumbers could answer her question, Mario's nose started twitching again. Another sneeze was coming on, but he really didn't want to give in to the urge. Not in front of the love of his life, the princess he always rescued. Mario began to inhale and shoved his forefinger under his nose, but the sneeze was coming whether he liked it or not. And it was going to be a big one.

"HaaaaaaAAAAAAAAAAAH... AAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHH..." Mario removed his forefinger, and aimed his head at the ground while Luigi and Peach could only look on in concern and fear. Then it came. "AAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHHHH-CHHHHHHHHHHHHHHHHHHHHHHOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO!"

Mario released another horribly loud and powerful sneeze, which not only caused the ground to shake some more, but also caused Luigi, Peach, and some other unfortunate onlookers to cringe. After a few seconds, Mario managed to catch his breath as his forefinger snapped to his nose and rubbed a few times.

"Oh, my. Bless you, Mario," Peach responded.

"Thanks. Well, unfortunately, both of us have exactly the same problem as you," Mario said.

"Is there anything you can do to help us figure out what's causing us to sneeze?" Luigi asked.

"I'll tell you one thing," Peach said. "Someone has told me about a curse that somebody has cast on the Mushroom Kingdom. And if I recall correctly, the curse is causing us to sneeze at random times."

"Then who cast it?" Luigi asked.

"I'm afraid the answer to that question is: who knows who cast it?"

"I bet it was... was... HAAAAAAAAAAAAAAAAAAAAAAH... HAAAAAAAAAAAAAAAAAAAAAAAAAAAH...!" Luigi inhaled to sneeze again and turned away from Peach at the last second. "HAH-CHIYOOOOOOOOOOOOOOOOOOOOOOOOOO!" After another loud sneeze, Luigi rubbed his nose on his hand and turned back to Peach. "I bet it was Bowser."

"I think it may be Bowser, too. He is evil, after all..."

After hearing this, Mario and Luigi decided that their mission was to defeat Bowser. They had done this at least a million times before, but it was what they did best. Mario and Luigi started to head out of the town square, with Peach unleashing another loud and feminine sneeze that caught them off-guard, but they otherwise ignored it. Along the way, both Mario and Luigi sneezed at random times, and they were always loud and powerful sneezes, but they usually forgot about them the second after they happened. They continued to hear others sneeze as well, but they did their best to ignore them, even when they started getting annoyed with it.

However, only when they met up with Wario did one of them finally take a moment to lose it. Their rival was inhaling, getting ready to sneeze, and not even bringing up an arm or hand to cover his mouth as he never did so when he sneezed, even in public. He didn't look like he could fight the sneeze, either.

"Huuuuh... HAAAAAAAAHHHHHHHHHH... HAAAAAAAAAAAAAAAAAH-CHHHHHHHHHOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO!" Wario sneezed directly onto Mario, and then blew him to the ground. Mario seemed more annoyed that he had been sneezed on than how his rival had just blown him down.

"Jeez, Wario, don't sneeze on me like that! It's gross!" Mario said as he got up.

"Sorry, bub, but I can't help it! This dang curse is driving me crazy!" Wario said as he rubbed his nose on his arm.

"Ugh, whatever. I don't have much time for this. We've got to get to Bowser's castle."

"Oh, sure! The bad guy we all know and hate is under this!" By the time Wario had finished this, Mario and Luigi had already left. He called out his next words, hoping that they would listen. "Hey! Mario! Luigi! He's not! He's not the one who put the curse on us! Somebody told me!"

To Wario's dismay, Mario and Luigi weren't even listening anymore, as they were more focused on the mystery that they were trying to solve.