Since the strange events of Easter and X Eggs, the Powerpuff Girls are placed in Seiyo Academy to investigate about these wandering children. Soon they start getting these strange eggs and an invitation to the Guardians. This can all go smoothly if their secret identities don't get out, but a few of the Guardians get suspicious of the girls. Rumors spreads, but what about Easter?

After a revenge plot against the Avengers fails, the Avengers are shrunk down to the size. To make matters worse, they are stuck in Easter eggs and surrounded by giant size kids with a lunatic god running around. How do they expect to get back to normal and stop that crazed god? And how can a couple of kids help them?

The Shugo Chara gang goes to middle school, leaving Yaya and Kairi behind. Instead of expecting an easy year, problem starts emerging. And just when they thought the battle for the Embryo was over, a new company arises and creates more chaos than before. Can they be able to stop this threat before its too late?