It is a fine afternoon all around for Clyde, as he walks towards his usual destination for a fine weekend, the Loud House. His chin high, his arms raised and his skip joyful, Clyde is excited to videogames nonstop with his old-time buddy Lincoln.

But as soon as he rings the doorbell, suddenly he gets dropped from the doorstep when it opened. At the top of his lungs, Clyde screams "AHHHHHHHHHHH!" as he descends on an aimless free fall. Swiftly, he gets sucked to a curved part of a tube and gets sucked to another, until he lands safely on a metal platform. Then, firefighting nitrogen gets sprayed on him. At the location he is in, it is clear who brought him in there.

"It seems my suction duct system has increasing potential for the market," a voice utters, which is obviously Lisa's, who turns her seat from behind to Clyde.

"Lisa, what's with the door? And why you have to bring me here that way?" he asks validly. "I could have just walked to the house and end up here."

"Negative," Lisa concludes, "The living room is preoccupied with a crass feud between my inferior siblings." The diminutive genius then enters in serious mode. "Now back to the matter at hand, I need your assistance."

"Me? Assistance for what?"

She then points him to a device that she is building, which has a setup that looks like two hair dryer chairs wired to a beacon and a computer. "Here is one of the opuses of my creation!"

"A state-of-the-art hair salon?"

"Nope!" she corrects him painfully, "Well, it resembles. I just rented those hair-abusing apparatuses from the local barber shop. But they will never witness the genius that comes with this." Lisa then proudly exposits about her newest invention, "This newest addition of my proud repertoire can instigate the ability to transmit an organism's personal consciousness to another functioning organism without interfering with the body's organ systems and function."

Of course, with Lisa's technical jargon, Clyde has a hard time interpreting Lisa's explanation. "So, this thing actually does…what?"

Plainly, Lisa utters, "It switches bodies."

"Oh, that thing. Wait, why did you create this machine anyway? Are you planning to switch bodies with someone else?"

"I was originally going to use this to one the members of the Michigan science council after they discredit my patent for a new formula for brake fluid, made from Charles' leftover chow. Sadly, those people are old geezers who can't understand 'why whippersnappers would invent silly stuff like this'. I just quoted what they really say. You may call it an exaggeration."

"Well, okay, I get you. But what is this machine for?"

"Oh, just to fool my sisters that this is really a hard dryer. Lincoln and I planned it."

"Oh yeah, speaking of which, where is Lincoln? Shouldn't he be helping you?"

"Yes. Why don't you go report to him after he is done appeasing my rambunctious sisters downstairs?" Lisa says sarcastically.

During that situation, Lincoln is actually trying to stop Lola and Lana from quarreling at each other. Their fight reaches to the extent that Leni, Luan, Lynn and Lucy have to join in to the fight as well. The reason for their crass fight is made unclear. But that is not the matter now for Lisa, since she does not want another trivial misunderstanding to get in her way with her scientific work.

Clyde even has to address this. "I wonder what's making them fight again…"

"It does not matter to anyone. Now help me or not?"

"What happens if not?"

"I get you transferred back to where you start."

And with that choice, Clyde aversely assists Lisa in finishing her body-switcher machine. It just needs a few repairs, additions to the gears and microchips and several maintenance checks before it can be fully functional for tests.

Meanwhile, to the Loud family feud, Lincoln gets up from being absorbed from the scuffle between Lola and Lana. Their literal fist fight went on with Lincoln trying to stop them, but he gets punched in the middle anyway.

As he recovers, Lincoln sees the twins being restrained by Luna and Lucy (for Lola), and Leni and Luan (for Lana). Though, each twin tries to break off.

"Lana, you chew like a dog!" Lola squeals.

"At least dogs are loyal, unlike you!" Lana lashes back, to the ire of the little prima donna.

"Lincoln, you gotta think of something," Luna pleads.

"My fingers can't handle them!" Leni remarks. "I just had them manicured!"

Lincoln finally stands up, despite attaining a lot of face injuries and pleads with them, "Lola, Lana, can you at least once act like you two are real twins with huge differences?"

"Well, if only she can stop using my dolls as alligator bait!" Lola complains.

"Hey! You released my earwigs and tadpoles to the wild!" Lana retorts.

"Because you placed them in my tea set! Yahhhh!" Just like that, Lola gets her released from her sisters' restraints and strikes towards Lana, again, thus resuming the feud once more.

Not wanting to attain more injuries, Lincoln moves away from the fight cloud that formed, only for one of his sister's arms to get sucked into the scuffle.

Back to Lisa and Clyde, the latter adds the final bolt to the machine, thus making Lisa's body switcher fully constructed.

"Now that's nearly a beauty," Clyde replies with a bit of hesitance.

Lisa then checks to her tablet, which contains a database for her laboratory operations. "Now, just to check the power source if there is sufficient energy to power it. And we can test the machine."

"Should we run a test now?"

She then checks her stats, which currently indicates that the invention is 87% functional. "Well, as inventors would go, we all learn from tests." With the look at her face giving it away, Lisa powers up the body switcher. "Now, after you, test subject."

"I thought I am your assistant?"

"Well, the title of 'assistant' is a generalization. You are also designated as a test subject."

Clyde then sighs at this insight. "Man, you better make your reasons clear."

"I think the word 'assistance' is already clear in your vocabulary. Now, shall we?"

"I am just thinking what would it feel like in your body…"

"None in particular, unless you also retain my acumen, which I doubt will stay stuck on my miniscule form…"

At that note, Clyde reluctantly sits at the right-side chair, while Lisa designates herself at the left-side. From a remote that is connected to the machine, the Loud family genius recharges the machine to ready itself to function. And with one press of a red button – a common trope for these kinds of situations – the machine operates to cognitively switch Clyde's consciousness to Lisa's body; and for Lisa's consciousness to Clyde's body. Throughout the entire procedure, both Lisa and Clyde are relaxed to their seats as the machine seamlessly transfer their souls to each other's bodies.

After the 3-minute mark, the body switcher stops, and the two children wake up from the procedure.

"Wha…what happened…?" Clyde in Lisa's body utters, "Why's my vision blurry?" He then wipes her eyes and her glasses, only for his sight to be clearer and to notice that he is effectively transferred to Lisa's body. "It worked. Lisa, it worked!"

"Of course, it worked," Lisa in Clyde's body boasts about. "It is all in the smallest fibers and neurons of the mind, assistant McBride."

"Great! So, what's next after this?"

"Well, I assume there is a lot of activities you can do with the stature of a body."

"Or to mine too."

Just at the thought of advantages the two can do with their switched bodies, Lisa/Clyde and Clyde/Lisa rushes from out of the room via the suction tube and do all sorts of activities that their ages provide.

Lisa in Clyde's body gets to enter an arcade and play the games there nonstop. After that, she feasts on an all-you-can-eat pizza buffet before she resumes to playing. In the end, she ends up sleeping on the reading area of a comic book store.

Meanwhile, Clyde on Lisa's body dives back to his experiences as a toddler by playing endlessly in the park and riding on some kindergarten-efficient transport like toy trikes, plastic trucks, shopping carts that look like plastic trucks and little bicycles with training wheels.

Even though switching bodies provide advantages, there are still disadvantages that it provides.

On Lisa's case, she unexpectedly gets a serious case of loose bowel movement. Because of that, she speeds fast to the female bathroom, only to get scrammed from the women for being a male. Though this scientific genius studied the male anatomy under biology, she has no idea how to operate Clyde's body.

For Clyde's case, because of her age, he gets questioned by some of the grownups he encountered. Apart from Lisa, who uses her lethargic social skills to stun the adults and make them earn her respect, Clyde has to hesitate around them, which allows for the adults to get reasonably concerned.

After that grand day off, the two converge on the doorstep and return to the lab to get switched back.

"Man, never thought I would feel so small out there…" Clyde in Lisa's body reacts.

"Well, better adapt that memory while I forget mine," Lisa in Clyde's body says in her wide eyes. "Must. Not. Recall. Time."

"What? What did you do?"

"Nothing. Just nothing. Let's switch back now!"

At Lisa's insistence, the two return to their seats as Lisa switches on the machine once more. The body switcher scans the physical components of the two, whose data causes it to shut down instantly.

Lisa presses the red button repeatedly, to no avail. "What? Why it's not working?"

"What happened? The machine's not working?!" At that note, the two on their switched forms look upon their creation with dismay.