Alex wakes suddenly as Kara is almost yanked from her grasp.

"Don't touch her!" Alex yells as she starts to stand and fight off the guard.

He easily pushes her back down. Alex meant what she said to Kara earlier about fighting to protect her until her last breath, as she stands up, she fights through the pain and tries to fight off the guard. She must have still been half asleep when the guard grabs Kara, because she didn't realize that Superman, is who she is trying to fight off.

He lets her stand before saying to her," You know that you always held her back from her full potential. You are the reason why she didn't take her rightful place as leader of the DEO or as the God that she is."

"Clark, this is the Red Kyptonite talking. It alters your brain, it makes you say things out of anger. You must fight it. I can't help you with an antidote, like we did for Kara while she was under the influence. You must be stronger. You must fight this. She said things that she didn't mean. She let thoughts that she tried to hide come to the surface. You must try to fight. Be her stronger, older cousin. Be her hero." Alex pleads, though she knows it's of no use. She couldn't even speak reason to Supergirl when this happened, she had to rely on the antidote that Maxwell Lord had developed. She knows that without the antidote, she is only speaking empty words.

Ripping Supergirl from Alex's grasp, he makes sure to pull her close enough to give her a warning once he has Kara in the other hand.

"You know that she doesn't belong with you. She deserves to live a full life, as a Kryptonian. Someone who should reign. Who should embrace her powers. The faster we rid her of you, the better off she will be."

Alex tries to push away from Superman, but he is not ready to let her go. "I will die before I let you corrupt her or hurt her," Alex tries to say through gritted teeth. She is afraid, not just for herself, but for what they can make Supergirl do if exposed to the Red Kryptonite let alone the Silver that Rhea has.

"That can be arranged," Superman says as he punches Alex, just to show his superiority.

"It's okay Clark. I know this isn't you. "Alex says as she tries to wipe away the blood that falls from her lip.

"You don't know anything," he says as Kara wakes and struggles to get out of his grasp, suddenly aware that she isn't in her sister's arms anymore.

"Clark!" Supergirl tries to break free from his hold. "What are you doing? Alex! What happened? Are you okay?" Supergirl tries to get away from Superman to get to her sister.

"Kara! Clark, he's under the influence of the Red and Silver Kryptonite!" Alex tries to say as Superman throws Kara towards the wall so that he can backhand Alex as she tries to walk towards Kara.

"Alex!" Supergirl yells as she watches her cousin hit her sister.

Alex drops to the ground, holding her face. "I'm okay. Stay where you are." She holds up her hand as if to try to make Kara stop.

Kara, ignoring Alex's pleas, rushes to her, putting herself in front of her sister to protect her from her cousin. "I will not let you hurt her." She says as she tries to appear brave, though she knows that deep down she isn't up to full strength.

"Supergirl. When will you let humans stop dictating how you live your life? Be a god. Use your power. Rule. Like we were always intended to do." Superman says as he stands with his arms crossed.

"You don't mean that Kal. We are supposed to help them, to protect them. Not hurt them." Supergirl says as she tries to help Alex stop the bleeding from her nose.

"Why do you bother with her? She isn't your family. I am. Stand with me or stand against me." He says, pulling Kara by her suits collar, away from Alex.

Alex tries to stand, to get to Kara. Kara waves her away. "It's okay Alex, I'll do what he wants." She says as she stops struggling.

"No, don't do this. Stronger together. Isn't that what you told me?" Alex says as she tries to get in between Superman and Supergirl.

"It is. You are right. But, I won't let any harm come to you. If going with him spares you, I'll do it." She says as she puts her arms up in the air, as if offering her defeat.

"No, we can figure this out together," Alex tries to say as she tries to grab Kara.

Suddenly, Superman grabs her and locks his powerful arms around Alex's neck. "I will end her, right now, if you don't come willingly."

Supergirl drops her head. "I will come with you. Please, just let her go." She says as she walks towards Alex and puts her hand around Kal's arm, trying to force him to lessen his grip on her big sister.

He pushes Supergirl out of the way and throws Alex into the other corner of the room, grabbing Supergirl's arm and dragging her out of the room.

Rhea observes the situation through her cameras, satisfied with how the synthetic Kryptonite is working. She didn't expect the red to blend with the silver. Superman no longer sees an enemy, he just has anger towards everyone he's ever had a bad thought about. The things he said to Alex, are all things he's thought at some point. Just never expressed because of his moral code. He learned to be human. Kara, was old enough to know what it meant to be a Kryptonian. That's why she is going to enjoy exposing Kara to her synthetic Kryptonite. It will make her lash out against Alex, the DEO, and even Superman.

"Kal! Please, you have to fight this! I'm not your enemy. Rhea is trying to turn us against each other to do her bidding." Kara pleads as she walks down the hall following Clark.

They reach a bigger room. Kara notices a throne in the middle of the room, and a small sparring area. Then she sees the chains in the corner and a chair with restraints in the other corner. She realizes that she is going to have to fight Clark. She hopes that she doesn't get exposed to the same form of Kryptonite that Clark has. Her heart drops thinking that Rhea may make her fight her sister. She is so caught up in her thoughts that she doesn't notice Clark on his knees in the opposite corner. Hands grabbing his head, as though they are trying to stop some form of pain.

"Kal!" As Kara starts to walk towards Clark, she immediately begins to feel sick. Noticing Rhea walk into the center of the room, green hues suddenly illuminate the room.

"I never imagined I'd have both of you on your knees before me. It's a sight I will always remember," she says as she sits on her throne. "Turn up the emitters and bring the agent in," she says, her voice free of any remorse.

"Leave my sister alone. You have what you want. You don't need her anymore." Kara says, struggling to stand. The emitters suddenly stripping her of any strength she recovered while asleep in Alex's arms.

"If I let her go, who would I use to hurt you? Superman is your blood, yes, but Alex, she is your sister, your home. Your whole life revolves around her and the DEO. There must be some pent-up frustration against that. They are using you to do their heavy lifting. You must have some resentment. I am going to help you discover that. When you have destroyed the two things that give you your humanity, then, you will understand how it feels to be stripped of someone close to you. Someone you would have died for. The loss is overwhelming." Rhea is standing at the end of her speech, anger rising. Her hate for the Kryptonians clear. "Bring her in!" She yells at the guards.

As a guard walks in with Alex, another grabs Kara and forces her to sit in the other chair in the room. The arm restraints close around her wrists. A green hue covering them. Kara tries to keep her head held high, not wanting her sister to see the weakness that the Kryptonite brings. She wants to appear brave so that Alex will not blame herself for what is about to happen. So that Alex knows that she will fight the synthetic Kryptonite. Most importantly, to try to convince herself that they will make it out of this.

Clark is chained up behind Rhea's throne. His shackles glowing green as well. "My Queen, you do not need to restrain me. Let me help," Superman says as he tries to control the pain on his face.

"Soon. I want you to watch this to erase any doubts you may have." Rhea says.

"Kara. Look at me. Kara! Don't stop looking at me," Alex yells as Rhea walks over to Kara. Alex struggles to get up to get to Kara, but is met with a kick to the back of her leg, bringing her to her knees. The guard grabs Alex and makes her watch Rhea approaching Kara. "It's going to be okay, we will get through this. Try to fight. I know you can do this, I know that you won't hurt me." Alex says to Kara as Rhea takes the syringe from the box sitting next to Kara's chair.

Kara tries to break free, but it's no use, she's took weak from the constant exposure from the Kryptonite. She tries to make a final plea to Rhea, "I know that it hurt losing Mon-El. I am devastated as well. He was the first person I ever loved. He showed me that people can create their own destiny. I loved him with my whole heart. I am sorry that he…that we lost him." Kara says, looking up at Rhea, tears in her eyes.

Rhea backhands Kara. "YOU ARE THE REASON MY SON IS DEAD!" she screams at Kara. "Her agency is why he is gone!" She yells pointing at Alex, "And THAT, is why she will die at your hand!" Rhea stabs Kara in the neck with the syringe.

"Ahhhhhh!" Kara screams as she looks up, trying to avoid Alex's eyes. Trying to focus on her voice. She tries to fight through the pain. The synthetic Kryptonite that Rhea injects her with causes the green to show in her eyes, followed by red, then silver.

"Kara!" Alex cries out. She tries to get up and to run to Kara, receiving a blow to the back of the head. She tries to crawl and feels the guards boot digging into her back, holding her in place. "Kara…please…you can fight this." Alex gets out through gritted teeth.

Kara's head drops. She is still for a few seconds, then she gasps for breath. "Al…Alex…" She tries to look over to Alex, the pain across her face evident.

"I'm here. I'm right here," Alex says, still trying to reach Kara.

"I didn't think you'd turn after the first dose, this will be fun." Rhea says, preparing to inject Kara with another syringe.

"No!" Alex screams. Feeling helpless, all Alex can do is watch her little sister scream out in pain. She wonders how much more of this Kara can take and how long she will be able to watch her sister suffer.