Even after Yugi Muto's reign as the King of Games went on a hiatus, Kaiba Corp and Industrial Illusions decided to become supporters in reconstructing Domino High School as the epiphany of dueling education. Thus, Domino High School was renamed Neo Domino Duel Academy (NDDA, for short) and was divided into four sections: the Synchro course, the Fusion course, the XYZ course, and the Standard course within the center of an island. The Synchro course taught their students to be the fastest duelists on the road, having special privileges to learn to participate in Acceleration Duels. The Fusion course specialized in deceiving their opponents with set cards and having a harsh regime of tactics to win duels. The XYZ course encouraged their students to make use of any card and put priorities in summoning as many monsters if possible. Last but not least, the Standard course enjoyed in making audiences smile with their spontaneous Action Duels. All students were ranked differently, specifically based upon the original Duel Academy: Osiris Red Dorm, Ra Yellow Dorm, and Obelisk Blue Dorm. These ranks made up your identity, your status, your life in school.

But things were going to be interesting with the four Sakaki brothers transferring to this school, each within different courses and ranks...

Let the games begin.